Introduction to Pangenomics

Event content

Pangenomes have become the trend in large-scale genomic studies, emerging as a response to both the limitation of linear genomes and the advancement of sequencing technologies that have resulted in a large number of individual genomes being available. Their major advantage is the ability to represent a larger set of samples (many individuals of a given species). This comes with an associated increase in computational complexity: the larger the samples are, the more computational power is needed to process, store, and represent the underlying data. In this tutorial we intend to give a primer to the topic of Pangenomics, and demonstrate at least one research application scenario through hands on work. We will also guide the user in utilising the HPC resources and services of the GWDG to run such analysis.

Learning goal

• General understanding of the theory behind Pangenomics and its applications
• Knowledge of the different pangenome construction tools & approaches available
• Ability to construct a Pangenome and use it for downstream analysis
• Familiarity with the Pangenomics tools available to use on the GWDG HPC cluster

Information about the event

Max. participants

50

Requirements

• General background in Life Sciences, basics of genomics
• Basic knowledge of command line usage (e.g. Bash)
• Python/Jupyter knowledge also of advantage

Speakers

Mohanad Hussein

Dr. Martin Leandro Paleico